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. 2020 Jun:127:104392.
doi: 10.1016/j.jcv.2020.104392. Epub 2020 Apr 28.

Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China

Jun Zhang  1 , Miao Yu  2 , Song Tong  1 , Lu-Yu Liu  1 , Liang-V Tang  3
Affiliations

Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China

Jun Zhang et al. J Clin Virol. 2020 Jun.

Abstract

Background: A few studies have revealed the clinical characteristics of hospitalized patients with COVID-19. However, predictive factors for the outcomes remain unclear.

Objective: Attempted to determine the predictive factors for the poor outcomes of patients with COVID-19.

Study design: This is a single-center, retrospective study. Clinical, laboratory, and treatment data were collected and analyzed from 111 hospitalized patients with laboratory-confirmed COVID-19 in Union Hospital. The gathered data of discharged and deteriorated patients were compared.

Results: Among these 111 patients, 93 patients were discharged and 18 patients were deteriorated. The lymphocyte count (0.56 G/L [0.47-0.63] vs 1.30 G/L [0.95-1.65]) was lower in the deteriorated group than those in the discharged group. The numbers of pulmonary lobe involved (5.00 [5.00-5.00] vs 4.00 [2.00-5.00]), serum C-reactive protein (CRP, 79.52 mg/L [61.25-102.98] vs 7.93 mg/L [3.14-22.50]), IL-6 (35.72 pg/mL [9.24-85.19] vs 5.09 pg/mL [3.16-9.72]), and IL-10 (5.35 pg/mL [4.48-7.84] vs 3.97 pg/mL [3.34-4.79]) concentrations in deteriorated patients were elevated compared with discharged patients. Multivariate logistic regression analysis showed that male gender (OR, 24.8 [1.8-342.1]), comorbidity (OR, 52.6 [3.6-776.4]), lymphopenia (OR, 17.3 [1.1-261.8]), and elevated CRP (OR, 96.5 [4.6-2017.6]) were the independent risk factors for the poor prognosis in COVID-19 patients.

Conclusions: This finding would facilitate the early identification of high-risk COVID-19 patients.

Keywords: Coronavirus disease 2019; Predictive factors; Prognosis.

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Conflict of interest statement

Declaration of Competing Interest None.

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