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Review
. 2020 Jun:55:67-73.
doi: 10.1016/j.mib.2020.03.006. Epub 2020 Apr 29.

The acid response network of Staphylococcus aureus

Chunyi Zhou  1 , Paul D Fey  2
Affiliations
Review

The acid response network of Staphylococcus aureus

Chunyi Zhou et al. Curr Opin Microbiol. 2020 Jun.

Abstract

Staphylococcus aureus colonizes or causes infection in a multitude of niches within a mammalian host. Many of these niches are acidic, yet specific pH resistance mechanisms that facilitate survival have not been thoroughly investigated. This review discusses recent studies documenting known acid resistance mechanisms in S. aureus and other staphylococcal species. However, studies that clearly define the regulation of the acid resistance regulon and potential interactions with weak organic acids in specific niches of the host including the skin and gut are yet to be defined.

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Figures

Figure 1.
Figure 1.
S. aureus JE2 was grown in Complete Defined Medium (CDM) (A) and further acidified with either HCl or acetic acid (HAc) at pH 6 (B), pH 5.5 (C), pH 5 (D), pH 4.5 (E) and pH 4.0 (F).
See this image and copyright information in PMC

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