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. 2020 Jul:353:104114.
doi: 10.1016/j.cellimm.2020.104114. Epub 2020 Apr 28.

Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?

Juliana Gil Melgaço  1 , Tamiris Azamor  2 , Ana Paula Dinis Ano Bom  2
Affiliations

Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?

Juliana Gil Melgaço et al. Cell Immunol. 2020 Jul.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. Perhaps T cell responses may be the key to solving those questions. SARS-CoV-2-specific memory T cells persist in peripheral blood and may be capable of providing effective information about protective immunity. The T cells studies can be helpful in elucidating the pathways for development of vaccines, therapies, and diagnostics for COVID-19 and for filling these immunology knowledge gaps.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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