COVID-19 patients with respiratory failure: what can we learn from aviation medicine?

doi:10.1016/j.bja.2020.04.012

. 2020 Sep;125(3):e280-e281.

doi: 10.1016/j.bja.2020.04.012. Epub 2020 Apr 18.

COVID-19 patients with respiratory failure: what can we learn from aviation medicine?

William Ottestad¹, Signe Søvik²

Affiliations

PMID: 32362340
PMCID: PMC7165289
DOI: 10.1016/j.bja.2020.04.012

COVID-19 patients with respiratory failure: what can we learn from aviation medicine?

William Ottestad et al. Br J Anaesth. 2020 Sep.

. 2020 Sep;125(3):e280-e281.

doi: 10.1016/j.bja.2020.04.012. Epub 2020 Apr 18.

Authors

William Ottestad¹, Signe Søvik²

Affiliations

¹ Oslo, Norway. Electronic address: williamottestad@gmail.com.
² Oslo, Norway.

PMID: 32362340
PMCID: PMC7165289
DOI: 10.1016/j.bja.2020.04.012

No abstract available

Keywords: COVID-19; acute respiratory distress syndrome; aviation medicine; hypocapnia; hypocapnic hypoxia; hypoxaemia; respiratory failure.

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Figures

**Fig 1**
Relation between arterial oxygen saturations ( $S a_{O_{2}}$ ) and arterial partial pressures of carbon dioxide ( $P a_{C O_{2}}$ ) in eight volunteers breathing air in a hypobaric chamber at ambient pressure 42.1 kPa, corresponding to a pressure altitude of ∼22 000 ft. Inspiratory oxygen pressure is 7.5 kPa. The model predicts that an increase in $P a_{C O_{2}}$ from 2.5 to 4.5 kPa would decrease $S a_{O_{2}}$ from 87% to 50%. R²=0.88, P<0.001.

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Comment in

Using applied lung physiology to understand COVID-19 patterns.
Komorowski M, Aberegg SK. Komorowski M, et al. Br J Anaesth. 2020 Sep;125(3):250-253. doi: 10.1016/j.bja.2020.05.019. Epub 2020 May 27. Br J Anaesth. 2020. PMID: 32536444 Free PMC article. No abstract available.

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Using applied lung physiology to understand COVID-19 patterns.
Komorowski M, Aberegg SK. Komorowski M, et al. Br J Anaesth. 2020 Sep;125(3):250-253. doi: 10.1016/j.bja.2020.05.019. Epub 2020 May 27. Br J Anaesth. 2020. PMID: 32536444 Free PMC article. No abstract available.
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References

1. Zhou F., Yu T., Du R. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062. - PMC - PubMed
1. Tian S., Hu W., Niu L., Liu H., Xu H., Xiao S.-Y. Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol Adv. 2020;15:700–704. Access Published February 28. - PMC - PubMed
1. Westendorp R.G., Blauw G.J., Frölich M., Simons R. Hypoxic syncope. Aviat Space Environ Med. 1997;68:410–414. - PubMed
1. Hamilton C., Steinlechner B., Gruber E., Simon P., Wollenek G. The oxygen dissociation curve: quantifying the shift. Perfusion. 2004;19:141–144. - PubMed
1. Ottestad W., Hansen T.A., Pradhan G., Stepanek J., Høiseth L.Ø., Kåsin J.I. Acute hypoxia in a simulated high-altitude airdrop scenario due to oxygen system failure. J Appl Physiol. 2017;123:1443–1450. - PubMed

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[1] Zhou F., Yu T., Du R. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062. - PMC - PubMed

[2] Zhou F., Yu T., Du R. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062. - PMC - PubMed

[3] Tian S., Hu W., Niu L., Liu H., Xu H., Xiao S.-Y. Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol Adv. 2020;15:700–704. Access Published February 28. - PMC - PubMed

[4] Tian S., Hu W., Niu L., Liu H., Xu H., Xiao S.-Y. Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol Adv. 2020;15:700–704. Access Published February 28. - PMC - PubMed

[5] Westendorp R.G., Blauw G.J., Frölich M., Simons R. Hypoxic syncope. Aviat Space Environ Med. 1997;68:410–414. - PubMed

[6] Westendorp R.G., Blauw G.J., Frölich M., Simons R. Hypoxic syncope. Aviat Space Environ Med. 1997;68:410–414. - PubMed

[7] Hamilton C., Steinlechner B., Gruber E., Simon P., Wollenek G. The oxygen dissociation curve: quantifying the shift. Perfusion. 2004;19:141–144. - PubMed

[8] Hamilton C., Steinlechner B., Gruber E., Simon P., Wollenek G. The oxygen dissociation curve: quantifying the shift. Perfusion. 2004;19:141–144. - PubMed

[9] Ottestad W., Hansen T.A., Pradhan G., Stepanek J., Høiseth L.Ø., Kåsin J.I. Acute hypoxia in a simulated high-altitude airdrop scenario due to oxygen system failure. J Appl Physiol. 2017;123:1443–1450. - PubMed

[10] Ottestad W., Hansen T.A., Pradhan G., Stepanek J., Høiseth L.Ø., Kåsin J.I. Acute hypoxia in a simulated high-altitude airdrop scenario due to oxygen system failure. J Appl Physiol. 2017;123:1443–1450. - PubMed

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COVID-19 patients with respiratory failure: what can we learn from aviation medicine?

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