COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal

doi:10.1016/j.healun.2020.03.012

Editorial

. 2020 May;39(5):405-407.

doi: 10.1016/j.healun.2020.03.012. Epub 2020 Mar 20.

COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal

Hasan K Siddiqi¹, Mandeep R Mehra²

Affiliations

¹ Department of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
² Department of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: mmehra@bwh.harvard.edu.

PMID: 32362390
PMCID: PMC7118652
DOI: 10.1016/j.healun.2020.03.012

Editorial

COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal

Hasan K Siddiqi et al. J Heart Lung Transplant. 2020 May.

. 2020 May;39(5):405-407.

doi: 10.1016/j.healun.2020.03.012. Epub 2020 Mar 20.

Authors

Hasan K Siddiqi¹, Mandeep R Mehra²

Affiliations

¹ Department of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
² Department of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: mmehra@bwh.harvard.edu.

PMID: 32362390
PMCID: PMC7118652
DOI: 10.1016/j.healun.2020.03.012

No abstract available

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Figures

**Figure 1**
Classification of COVID-19 disease states and potential therapeutic targets. The figure illustrates 3 escalating phases of COVID-19 disease progression, with associated signs, symptoms, and potential phase-specific therapies. ARDS, acute respiratory distress syndrome; CRP, C-reactive protein; JAK, janus kinase; LDH, lactate dehydrogenase; NT-proBNP, N-terminal pro B-type natriuretic peptide; SIRS, systemic inflammatory response syndrome; GM-CSF, Granulocyte Macrophage Colony Stimulating Factor.

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Comment in

COVID-19: Timing is Important.
de Simone G, Mancusi C. de Simone G, et al. Eur J Intern Med. 2020 Jul;77:134-135. doi: 10.1016/j.ejim.2020.04.019. Epub 2020 Apr 13. Eur J Intern Med. 2020. PMID: 32362362 Free PMC article. No abstract available.

Comment on

Epidemiologic and clinical characteristics of heart transplant recipients during the 2019 coronavirus outbreak in Wuhan, China: A descriptive survey report.
Ren ZL, Hu R, Wang ZW, Zhang M, Ruan YL, Wu ZY, Wu HB, Hu XP, Hu ZP, Ren W, Li LC, Dai FF, Liu H, Cai X. Ren ZL, et al. J Heart Lung Transplant. 2020 May;39(5):412-417. doi: 10.1016/j.healun.2020.03.008. Epub 2020 Mar 25. J Heart Lung Transplant. 2020. PMID: 32362392 Free PMC article.

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References

1. Novel coronavirus pneumonia emergency response epidemiology team The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China [in Chinese] Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41:145–151. - PubMed
1. Wang M, Cao R, Zhang L. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. - PMC - PubMed
1. Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 [e-pub ahead of print]. N Engl J Med doi: 10.1056/NEJMoa2001282, Accessed March 15, 2020. - PMC - PubMed
1. Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020;395:473–475. - PMC - PubMed
1. Li F, Cai J, Dong N. First cases of COVID-19 in heart transplantation From China. J Heart Lung Transplant. 2020;39:418–419. - PMC - PubMed

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[1] Novel coronavirus pneumonia emergency response epidemiology team The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China [in Chinese] Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41:145–151. - PubMed

[2] Novel coronavirus pneumonia emergency response epidemiology team The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China [in Chinese] Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41:145–151. - PubMed

[3] Wang M, Cao R, Zhang L. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. - PMC - PubMed

[4] Wang M, Cao R, Zhang L. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. - PMC - PubMed

[5] Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 [e-pub ahead of print]. N Engl J Med doi: 10.1056/NEJMoa2001282, Accessed March 15, 2020. - PMC - PubMed

[6] Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 [e-pub ahead of print]. N Engl J Med doi: 10.1056/NEJMoa2001282, Accessed March 15, 2020. - PMC - PubMed

[7] Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020;395:473–475. - PMC - PubMed

[8] Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020;395:473–475. - PMC - PubMed

[9] Li F, Cai J, Dong N. First cases of COVID-19 in heart transplantation From China. J Heart Lung Transplant. 2020;39:418–419. - PMC - PubMed

[10] Li F, Cai J, Dong N. First cases of COVID-19 in heart transplantation From China. J Heart Lung Transplant. 2020;39:418–419. - PMC - PubMed

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COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal

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COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal

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