Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 May;39(5):405-407.
doi: 10.1016/j.healun.2020.03.012. Epub 2020 Mar 20.

COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal

Hasan K Siddiqi  1 , Mandeep R Mehra  2
Affiliations
Editorial

COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal

Hasan K Siddiqi et al. J Heart Lung Transplant. 2020 May.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Classification of COVID-19 disease states and potential therapeutic targets. The figure illustrates 3 escalating phases of COVID-19 disease progression, with associated signs, symptoms, and potential phase-specific therapies. ARDS, acute respiratory distress syndrome; CRP, C-reactive protein; JAK, janus kinase; LDH, lactate dehydrogenase; NT-proBNP, N-terminal pro B-type natriuretic peptide; SIRS, systemic inflammatory response syndrome; GM-CSF, Granulocyte Macrophage Colony Stimulating Factor.
See this image and copyright information in PMC

Comment in

  • COVID-19: Timing is Important.
    de Simone G, Mancusi C. de Simone G, et al. Eur J Intern Med. 2020 Jul;77:134-135. doi: 10.1016/j.ejim.2020.04.019. Epub 2020 Apr 13. Eur J Intern Med. 2020. PMID: 32362362 Free PMC article. No abstract available.

Comment on

References

    1. Novel coronavirus pneumonia emergency response epidemiology team The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China [in Chinese] Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41:145–151. - PubMed
    1. Wang M, Cao R, Zhang L. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. - PMC - PubMed
    1. Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 [e-pub ahead of print]. N Engl J Med doi: 10.1056/NEJMoa2001282, Accessed March 15, 2020. - PMC - PubMed
    1. Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020;395:473–475. - PMC - PubMed
    1. Li F, Cai J, Dong N. First cases of COVID-19 in heart transplantation From China. J Heart Lung Transplant. 2020;39:418–419. - PMC - PubMed