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. 2020 Apr 17:8:127.
doi: 10.3389/fped.2020.00127. eCollection 2020.

Potential Impact of Umbilical-Cord-Blood Procalcitonin-Based Algorithm on Antibiotics Exposure in Neonates With Suspected Early-Onset Sepsis

Noémie Huetz  1 , Elise Launay  2 , Géraldine Gascoin  1   3 , Bertrand Leboucher  1   3 , Christophe Savagner  1 , Jean B Muller  4 , Sophie Denizot  5 , Cécile Boscher  4 , Jocelyne Caillon  6 , Damien Masson  7 , Christèle Gras Le Guen  2
Affiliations

Potential Impact of Umbilical-Cord-Blood Procalcitonin-Based Algorithm on Antibiotics Exposure in Neonates With Suspected Early-Onset Sepsis

Noémie Huetz et al. Front Pediatr. .

Abstract

Context: The incidence of early-onset neonatal infection has greatly decreased, but a new diagnostic approach is needed to avoid overdiagnosis and overtreatment. The aim of this study was to assess the potential impact of an algorithm incorporating umbilical-cord-blood procalcitonin (PCT) level on neonatal antibiotics prescription rate as compared with current practice. Material and methods: We conducted a prospective study in three maternity wards in France. All term and preterm neonates with the usual risk factors for neonatal group B Streptococcus infection were eligible for umbilical-cord-blood PCT testing. We compared the proportion of neonates who were exposed early to antibiotics (before 6 days of life) to that of neonates for whom antibiotics prescription would be indicated according to the PCT-based algorithm. Results: Among the 3,080 neonates included, 1 neonate presented with certain infection and 38 neonates with probable infection. The global antibiotics prescription rate was 4.6% [95% confidence interval (CI), 4.1-5]. With the PCT-based algorithm, the potential decrease in prescription rate would be 1.8% (95% CI, 1.3-2.3), corresponding to a 39% (95% CI, 37.3-40.7) relative reduction in antibiotics exposure (p < 0.05). Conclusion: These results suggest that the umbilical-cord-blood PCT-based algorithm could significantly help the clinicians in their antibiotic prescription decision to decrease neonatal antibiotics exposure as compared with current practice. If validated in a larger interventional randomized study, this approach could help clinicians stratify the risk of early-onset neonatal infection and initiate early antibiotics treatment in newborns at high risk of infection while limiting the deleterious effects of useless prescriptions in non-infected newborns.

Keywords: antibiotic stewardship; biomarkers; decrease antibiotics exposure; early-onset neonatal infection; newborns; risk stratification; screening tool.

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Figures

Figure 1
Figure 1
Procalcitonin (PCT)-based algorithm (2017).
Figure 2
Figure 2
Flowchart of newborns in the study.
See this image and copyright information in PMC

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