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Review
. 2020 Mar 13;4(5):631-645.
doi: 10.1002/hep4.1503. eCollection 2020 May.

Drug-Induced Liver Injury in GI Practice

Naemat Sandhu  1 , Victor Navarro  1
Affiliations
Review

Drug-Induced Liver Injury in GI Practice

Naemat Sandhu et al. Hepatol Commun. .

Abstract

Although drug-induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States. It is one of the most challenging diagnoses encountered by gastroenterologists. The development of various drug injury networks has played a vital role in expanding our knowledge regarding drug-related and herbal and dietary supplement-related liver injury. In this review, we discuss what defines liver injury, epidemiology of DILI, its biochemical and pathologic patterns, and management.

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Figures

Fig. 1
Fig. 1
Mechanism of direct and immune mediated pathways of DILI. Abbreviations: RM, reactive metabolite; ROS, reactive oxygen species.
Fig. 2
Fig. 2
Approach to diagnosis of DILI. Abbreviations: ANA, antinuclear antibody; ASMA, anti–smooth muscle actin; EtOH, ethanol; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; HEV, hepatitis E virus; HSV, herpes simplex virus; IgG, immunoglobulin G; IgM, immunoglobulin M; LDH, lactate dehydrogenase.
See this image and copyright information in PMC

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