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Review
. 2020 Jul;31(7):1380-1383.
doi: 10.1681/ASN.2020040419. Epub 2020 May 4.

Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology

Daniel Batlle  1 , Maria Jose Soler  2 , Matthew A Sparks  3   4 , Swapnil Hiremath  5 , Andrew M South  6 , Paul A Welling  7 , Sundararaman Swaminathan  8 ; COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group
Collaborators, Affiliations
Review

Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology

Daniel Batlle et al. J Am Soc Nephrol. 2020 Jul.
No abstract available

Keywords: ACE2; Macrophage; Thrombotic; Acute kidney Injury; COVID-19.

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Figures

Figure 1.
Figure 1.
Single-cell RNA of SARS-COV-2 receptor (ACE2) and known priming proteases in the kidney. There is no clear correspondence in single-cell RNA between ACE2 and TMPRSS2. EC, endothelial cell; PT, proximal tubule (S1, Segment one; S2 Segment two, S3 Segment three); LH(DL), loop of henle(descending thin limb); LH(AL), loop of henle(descending limb type one [#type 1] and type two [type #2]); DCT, distal convoluted tubule; CNT, connecting tubule; PC, principal cell; IC-A, alpha intercalated cell; IC-B, beta intercalated cell; pct. exp, percentexpressed. Data were extracted with permission from human kidney single-cell RNA-sequencing data.,
Figure 2.
Figure 2.
Targeting of ACE2 by SARS-CoV-2 results in angiotensin dysregulation, innate and adaptive immune pathway activation, and hypercoagulation to result in organ injury and AKI associated with COVID-19. Organ crosstalk between the injured lungs, the heart, and the kidney may further propagate injury. CD8+ T-cells and natural killer cells can restrain macrophage activation and are potential targets for SARS-CoV-2. Ang 1–7, angiotensin 1–7; ATN, acute tubular necrosis. ACE2, angiotensin converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TMPRSS2, transmembrane protease, serine 2.
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References

    1. Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, et al. .: Covid-19 in critically ill patients in the seattle region - case series [published online ahead of print Mar 30, 2020]. N Engl J Med doi:10.1056/NEJMoa2004500 - PMC - PubMed
    1. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. .: Kidney disease is associated with in-hospital death of patients with COVID-19 [published online ahead of print Mar 20, 2020]. Kidney Int doi:10.1016/j.kint.2020.03.005 - PMC - PubMed
    1. Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, et al. : Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China [published online ahead of print Apr 9, 2020]. Kidney International doi:10.1016/j.kint.2020.04.003 - PMC - PubMed
    1. Tang N, Li D, Wang X, Sun Z: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 18: 844–847, 2020. - PMC - PubMed
    1. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. .: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 395: 1054–1062, 2020. - PMC - PubMed

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