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Review
. 2021 May 1;43(4):e535-e538.
doi: 10.1097/MPH.0000000000001811.

Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type I and Literature Review

Trevor B Cabrera  1 , Wei Wang  2 , Sireesha Yedururi  3 , John M Slopis  4 , Raphael E Steiner  5 , Michael E Rytting  1 , Branko Cuglievan  1
Affiliations
Review

Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type I and Literature Review

Trevor B Cabrera et al. J Pediatr Hematol Oncol. .

Abstract

Neurofibromatosis Type 1 (NF1) is a genetic disorder with an incidence of 1 in 2600 to 3000 individuals. It is a clinical diagnosis characterized by café-au-lait macules, neurofibromas, and axillary and/or groin freckling. Because of genetic mutations in the NF1 gene affecting the Ras/mitogen-activated protein kinase pathway, there is also risk of associated soft tissue sarcomas and hematologic malignancies. However, reports of classic Hodgkin lymphoma in patients with NF1 are sparse. We report an adolescent with NF1 who developed classic Hodgkin lymphoma. Although there is an unclear association between mutations in the NF1 gene and classic Hodgkin lymphoma, further studies are warranted.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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