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Review
. 2020 Apr 21:15:557-566.
doi: 10.2147/CIA.S245147. eCollection 2020.

Influencing Factors and Exercise Intervention of Cognitive Impairment in Elderly Patients with Chronic Obstructive Pulmonary Disease

Ting Wang  1 , Lijuan Mao  1 , Jihong Wang  1 , Peijun Li  1 , Xiaodan Liu  2   3 , Weibing Wu  1
Affiliations
Review

Influencing Factors and Exercise Intervention of Cognitive Impairment in Elderly Patients with Chronic Obstructive Pulmonary Disease

Ting Wang et al. Clin Interv Aging. .

Abstract

Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterized by airflow limitation in the elderly. Airflow limitation is partially reversible and progressive. COPD not only causes a gradual decline in lung function but also affects the function of other systems throughout the body; it also has adverse effects on the central nervous system that can lead to cognitive impairment, especially in elderly patients. Therefore, understanding the influencing factors of cognitive impairment in elderly patients with COPD and applying early intervention are crucial in improving the quality of life of patients and reducing the burden on their families and society. This article mainly discusses the related factors of cognitive impairment in elderly patients with COPD and expands the possible mechanism of exercise in improving cognitive impairment in patients with COPD to provide a reference for the clinical prevention and treatment of cognitive impairment in elderly patients with COPD.

Keywords: chronic obstructive pulmonary disease; cognitive function; elderly people; exercise training; influencing factors.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The possible mechanism of exercise improving cognitive impairment in the elderly with COPD. Abbreviations: NE, norepinephrine; DA, dopamine; 5-HT, 5-hydroxytryptamine; IL-10, interleukin-10; IL-6, interleukin-6; CRP, C-reactive protein; TNF-α, tumor necrosis factor-α; PaO2, partial arterial blood oxygen pressure; PaCO2, partial arterial carbon dioxide pressure; VEGF, vascular endothelial growth factor; IGF-1, insulin-like growth factor-1.
See this image and copyright information in PMC

References

    1. Singh D, Agusti A, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019. Eur Respir J. 2019;53(5):1900164. doi:10.1183/13993003.00164-2019 - DOI - PubMed
    1. Jemal A, Ward E, Hao Y, Thun M. Trends in the leading causes of death in the United States, 1970–2002. JAMA. 2005;294(10):1255–1259. doi:10.1001/jama.294.10.1255 - DOI - PubMed
    1. Cavailles A, Brinchault-Rabin G, Dixmier A, et al. Comorbidities of COPD. Eur Respir Rev. 2013;22(130):454–475. doi:10.1183/09059180.00008612 - DOI - PMC - PubMed
    1. O’Conor R, Muellers K, Arvanitis M, et al. Effects of health literacy and cognitive abilities on COPD self-management behaviors: a prospective cohort study. Respir Med. 2019;160:105630. doi:10.1016/j.rmed.2019.02.006 - DOI - PMC - PubMed
    1. Campbell NL, Boustani MA, Skopelja EN, Gao S, Unverzagt FW, Murray MD. Medication adherence in older adults with cognitive impairment: a systematic evidence-based review. Am J Geriatr Pharmacother. 2012;10(3):165–177. doi:10.1016/j.amjopharm.2012.04.004 - DOI - PubMed

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