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. 2020 Mar 28;7(4):ofaa108.
doi: 10.1093/ofid/ofaa108. eCollection 2020 Apr.

Lymphocyte Subsets in HIV-Exposed Uninfected Infants: The Impact of Neonatal Postexposure Prophylaxis With Zidovudine

Beat M Greiter  1 , Christian R Kahlert  2   3 , Nadia Eberhard  4 , Leila Sultan-Beyer  5 , Christoph Berger  1 , Paolo Paioni  1
Affiliations

Lymphocyte Subsets in HIV-Exposed Uninfected Infants: The Impact of Neonatal Postexposure Prophylaxis With Zidovudine

Beat M Greiter et al. Open Forum Infect Dis. .

Abstract

HIV-exposed, uninfected (HEU) infants receiving neonatal postexposure prophylaxis with zidovudine showed nonsignificant trends of lower CD4 and CD8 T cells as well as CD19 B cells than those who did not, suggesting toxicity that might impact the overall health of HEU children.

Keywords: HIV-exposed uninfected infants; adjusted mean difference; lymphocyte subsets; neonatal postexposure prophylaxis; zidovudine.

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Figures

Figure 1.
Figure 1.
Unadjusted means (with 95% CI) for changes in distribution of CD19 B cells (A), CD4 (B) and CD8 (C) T cells as well as MCV (D) with age by neonatal PEP exposure status. MCV, mean corpuscular volume; PEP, postexposure prophylaxis.
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