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. 2019 Dec 2:4:e252-e263.
doi: 10.5114/amsad.2019.90152. eCollection 2019.

Non-traumatic and non-drug-induced rhabdomyolysis

Genovefa Kolovou  1 , Philip Cokkinos  1 , Helen Bilianou  2 , Vana Kolovou  1   3 , Niki Katsiki  4 , Sophie Mavrogeni  1
Affiliations

Non-traumatic and non-drug-induced rhabdomyolysis

Genovefa Kolovou et al. Arch Med Sci Atheroscler Dis. .

Abstract

Rhabdomyolysis (RM), a fortunately rare disease of the striated muscle cells, is a complication of non-traumatic (congenital (glycogen storage disease, discrete mitochondrial myopathies and various muscular dystrophies) or acquired (alcoholic myopathy, systemic diseases, arterial occlusion, viral illness or bacterial sepsis)) and traumatic conditions. Additionally, RM can occur in some individuals under specific circumstances such as toxic substance use and illicit drug abuse. Lipid-lowering drugs in particular are capable of causing RM. This comprehensive review will focus on non-traumatic and non-drug-induced RM. Moreover, the pathology of RM, its clinical manifestation and biochemical effects, and finally its management will be discussed.

Keywords: dystrophy; myoglobulin; myopathy; rhabdomyolysis.

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Conflict of interest statement

The authors declare no conflict of interest.

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