Dose Issues in Cancer Chemotherapy

Abstract

In this review, human methotrexate dosing regimens, as well as their relationship to data from in vitro cell culture and in vivo animal and human studies, are discussed. Low-dose, intermediate-dose, and high-dose therapies are covered. Since in vitro and in vivo screenings of potential cancer drugs are commonplace in the development of cancer chemotherapy, comparisons of the three criteria for effectiveness are important.

Keywords: Animal dose; Animal-to-human extrapolation; Cell culture dose; Human dose; Methotrexate; Pharmacologically active drug concentration.