Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19

doi:10.1016/j.drudis.2020.04.021

. 2020 Jul;25(7):1121-1123.

doi: 10.1016/j.drudis.2020.04.021. Epub 2020 May 1.

Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19

Ilaria D'Acquarica¹, Israel Agranat²

Affiliations

¹ Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Rome, Italy. Electronic address: ilaria.dacquarica@uniroma1.it.
² Organic Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel. Electronic address: isri.agranat@mail.huji.ac.il.

PMID: 32371138
PMCID: PMC7194068
DOI: 10.1016/j.drudis.2020.04.021

Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19

Ilaria D'Acquarica et al. Drug Discov Today. 2020 Jul.

. 2020 Jul;25(7):1121-1123.

doi: 10.1016/j.drudis.2020.04.021. Epub 2020 May 1.

Authors

Ilaria D'Acquarica¹, Israel Agranat²

Affiliations

¹ Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Rome, Italy. Electronic address: ilaria.dacquarica@uniroma1.it.
² Organic Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel. Electronic address: isri.agranat@mail.huji.ac.il.

PMID: 32371138
PMCID: PMC7194068
DOI: 10.1016/j.drudis.2020.04.021

No abstract available

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Figures

**Figure 1**
Chemical structures of the paired (S)-(+) and (R)-(–) enantiomers of chloroquine (CQ) and hydroxychloroquine (HCQ). CAS Numbers: (S)-(+)-CQ: [58175-86-3]; (R)-(–)-CQ: [58175-87-4]; (S)-(+)-HCQ: [137433-24-0]; (R)-(–)-HCQ: [137433-23-9].

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References

1. Li G., De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Nat. Rev. Drug Discov. 2020;19:149–150. - PubMed
1. Gao J., et al. Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci. Trends. 2020;14:72–73. - PubMed
1. Wang M., et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. - PMC - PubMed
1. Colson P., et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int. J. Antimicrob. Agents. 2020;55:105932. - PMC - PubMed
1. Liu J., et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov. 2020;6:16–19. - PMC - PubMed

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[1] Li G., De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Nat. Rev. Drug Discov. 2020;19:149–150. - PubMed

[2] Li G., De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Nat. Rev. Drug Discov. 2020;19:149–150. - PubMed

[3] Gao J., et al. Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci. Trends. 2020;14:72–73. - PubMed

[4] Gao J., et al. Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci. Trends. 2020;14:72–73. - PubMed

[5] Wang M., et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. - PMC - PubMed

[6] Wang M., et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. - PMC - PubMed

[7] Colson P., et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int. J. Antimicrob. Agents. 2020;55:105932. - PMC - PubMed

[8] Colson P., et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int. J. Antimicrob. Agents. 2020;55:105932. - PMC - PubMed

[9] Liu J., et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov. 2020;6:16–19. - PMC - PubMed

[10] Liu J., et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov. 2020;6:16–19. - PMC - PubMed

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Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19

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