Parental origin of monosomic chromosomes in near-haploid acute lymphoblastic leukemia

Affiliations

¹ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. kristina.lundin_strom@med.lu.se.
² Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.
³ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
⁴ Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
⁵ Department of Pediatrics, Linköping University Hospital, Linköping, Sweden.
⁶ Department of Pediatrics, Skåne University Hospital, Lund, Sweden.
⁷ Department of Clinical Genetics and Pathology, Division of Laboratory Medicine, Lund, Sweden.

Kristina B Lundin-Ström et al. Blood Cancer J. 2020.

. 2020 May 5;10(5):51.

doi: 10.1038/s41408-020-0317-2.

¹ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. kristina.lundin_strom@med.lu.se.
² Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.
³ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
⁴ Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
⁵ Department of Pediatrics, Linköping University Hospital, Linköping, Sweden.
⁶ Department of Pediatrics, Skåne University Hospital, Lund, Sweden.
⁷ Department of Clinical Genetics and Pathology, Division of Laboratory Medicine, Lund, Sweden.

No abstract available

Conflict of interest statement

The authors declare that they have no conflict of interest.

1. Pui C-H, et al. Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid <45 line. Blood. 1990;75:1170–1177. doi: 10.1182/blood.V75.5.1170.1170. - DOI - PubMed
1. Holmfeldt L, et al. The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet. 2013;45:242–252. doi: 10.1038/ng.2532. - DOI - PMC - PubMed
1. Verma RS, Macera MJ, Silver RT, Coleman M. Origin of near-haploidy in malignant hematopoietic cells. Leuk. Res. 1988;12:941–950. doi: 10.1016/0145-2126(88)90022-7. - DOI - PubMed
1. Gimelbrant A, Hutchinson JN, Thompson BR, Chess A. Widespread monoallelic expression on human autosomes. Science. 2007;318:1136–1140. doi: 10.1126/science.1148910. - DOI - PubMed
1. Eggermann T, et al. Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci. Clin. Epigenet. 2015;7:123. doi: 10.1186/s13148-015-0143-8. - DOI - PMC - PubMed