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. 2021 Jan;199(1):338-343.
doi: 10.1007/s12011-020-02149-0. Epub 2020 May 5.

Speciation Analysis of Chromium in Chromium-Enriched Yeast by Ion Chromatography-Inductively Coupled Plasma Mass Spectrometry

Shuang-Qing Zhang  1 , Sui-Han Cheng  2 , Shi Shen  3 , Bi-Ying Luo  2 , Yan Zhang  2
Affiliations

Speciation Analysis of Chromium in Chromium-Enriched Yeast by Ion Chromatography-Inductively Coupled Plasma Mass Spectrometry

Shuang-Qing Zhang et al. Biol Trace Elem Res. 2021 Jan.

Abstract

Chromium-enriched yeast (CrY) is a popular Cr dietary supplement, but suitable speciation analysis of highly toxic Cr(VI) in CrY is not available. Ion chromatography-inductively coupled plasma mass spectrometry method was firstly developed and validated for the quantification of Cr(III) and Cr(VI). Ultrasound-assisted weakly alkaline EDTA solution combined with boiling was used to extract two Cr species in CrY. Two species were separated on two successive anion-exchange columns using a mobile phase of 0.6 mmol/L EDTA and 76 mmol/L NH4NO3 solution. The method was sensitive, accurate (92.4-100.9%), and precise (0.8-3.1%). Species of Cr(VI) were not found in CrY.

Keywords: Chromium; Chromium-enriched yeast; Ion chromatography-inductively coupled plasma mass spectrometry; Speciation.

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