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. 2020 Jul;190(1):e45-e48.
doi: 10.1111/bjh.16702. Epub 2020 May 5.

Association between plasma and urinary orosomucoid and chronic kidney disease in adults with sickle cell disease

Marina Jerebtsova  1 , Ammanuel Taye  2 , Nathan Smith  2 , Nowah Afangbedji  3 , Daniel Stokes  3 , Xiaomei Niu  3 , Sharmin Diaz  3 , James G Taylor 6th  1   2   3 , Sergei Nekhai  1   2   3
Affiliations

Association between plasma and urinary orosomucoid and chronic kidney disease in adults with sickle cell disease

Marina Jerebtsova et al. Br J Haematol. 2020 Jul.
No abstract available

Keywords: chronic kidney disease; orosomucoid; sickle cell disease; urinary biomarker.

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Conflict of interest statement

Conflict of interest

The authors have no conflict of interest to declare.

Figures

Fig 1.
Fig 1.
Correlation of PORM and UORM with CKD and eGFR in HbSS and HbSC patients. (A, B) Correlation of PORM (A) and UORM/CRE (B) levels with stages of CKD in HbSS patients. (C) ROC analysis for differentiation of no CKD (stage 0) and with CKD (stages 1–4) in HbSS patients. (D and G) Correlation of eGFR with PORM concentrations in HbSS (D) and HbSC (G) patients. (E and H) Correlation of eGFR with UORM in HbSS (E) and HbSC (H) patients. (F and I) Correlation of PORM with UORM levels (UORM/CRE ratios) in HbSS (F) and HbSC (I) patients. Pearson correlation coefficient (r) is shown. UORM concentrations were normalised on CRE as a ratio. PORM, plasma orosomucoid; UORM, urinary orosomucoid; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; ROC, receiver-operating characteristic; CRE, urinary creatinine.
See this image and copyright information in PMC

References

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