Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr 21:14:371.
doi: 10.3389/fnins.2020.00371. eCollection 2020.

Irritable Bowel Syndrome: Manipulating the Endocannabinoid System as First-Line Treatment

Viola Brugnatelli  1 , Fabio Turco  2 , Ulderico Freo  3 , Gastone Zanette  1
Affiliations

Irritable Bowel Syndrome: Manipulating the Endocannabinoid System as First-Line Treatment

Viola Brugnatelli et al. Front Neurosci. .
No abstract available

Keywords: CB1; CB2; CBD; IBS; PEA; THC; TRPV1; endocannabinoid.

PubMed Disclaimer

Figures

Figure 1
Figure 1
IBS features modulated by ECS. Schematic representation of the Endocannabinoid System (ECS) involvement in lBS features and its interaction with hypothalamic-pituitary-adrenal (HPA) axis throughout day/night. The black arrows indicate the receptors and the target sites controlled by ECS components. In red are shown the agents capable of modulating ECS activities that may be useful to improve IBS symptoms, such as motility, visceral pain, and low-grade inflammation. Blue arrows indicate a decrease in the functions targeted by ECS stimulation. TRPV I, Transient receptor potential vanilloid I; CB I, Cannabinoid Receptor I; CB2: Cannabinoid Receptor 2; TRPM8, Transient receptor potential melastatin 8; CBD, cannabidiol; THC, tetrahydrocannabinol; FAAH, fatty acid amide hydrolase; COX, cyclooxigenase; MAGL, monoacyl glycerol lipase; PEA, palmitoylethanolamide; PPARa: Peroxisome proliferator-activated receptor a.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Acharya N., Penukonda S., Shcheglova T., Hagymasi A. T., Basu S., Srivastava P. K. (2017). Endocannabinoid system acts as a regulator of immune homeostasis in the gut. Proc Natl Acad Sci, U. S. A. 114, 5005–5010. 10.1073/pnas.1612177114 - DOI - PMC - PubMed
    1. Ahluwalia J., Urban L., Capogna M., Bevan S., Nagy I. (2000). Cannabinoid 1receptors are expressed in nociceptive primary sensory neurons. Neuroscience. 100, 685–688. 10.1016/S0306-4522(00)00389-4 - DOI - PubMed
    1. Ahn E. H., Kim D. W., Shin M. J., Kim H. R., Kim S. M., Woo S. J., et al. . (2014). PEP-1-PEA-15 protects against toxin-induced neuronal damage in a mouse model of Parkinson's disease. Biochim Biophysa Acta. 1840, 1686–1700 10.1016/j.bbagen.2014.01.004 - DOI - PubMed
    1. Akbar A., Yiangou Y., Facer P., Walters J. R., Anand P., Ghosh S. (2008). Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut. 57, 923–929. 10.1136/gut.2007.138982 - DOI - PMC - PubMed
    1. Barbara G., Cremon C., Bellacosa L., De Giorgio R., Santos J., Vicario M., et al. (2014). 714 randomized placebo-controlled multicenter study on the effect of palmitoyl-ethanolamide and polydatin on immune activation in patients with irritable bowel syndrome. Gastroenterology 146:S-124. 10.1016/S0016-5085(14)60446-7 - DOI

LinkOut - more resources