Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Apr 21:11:811.
doi: 10.3389/fimmu.2020.00811. eCollection 2020.

Commentary: Origin and evolution of pathogenic coronaviruses

Affiliations
Comment

Commentary: Origin and evolution of pathogenic coronaviruses

Shun Adachi et al. Front Immunol. .
No abstract available

Keywords: COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; evolution; origin; pathogenic coronaviruses.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Emergence of coronaviruses pathogenic for humans from ancestral bat viruses. Diversification of SARS-CoV, SARS-CoV-2, and MERS-CoV from ancestor viruses by possible genome recombinations is illustrated. Two major variable regions among viral genomes (S and orf8 genes) are indicated. The variations are most probably due to the high recombination potentials of the coronaviruses. For details, refer to the titled review article in this commentary.

Comment on

References

    1. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. . Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. (2020) 395:565–74. 10.1016/S0140-6736(20)30251-8 - DOI - PMC - PubMed
    1. Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, et al. . Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host Microbe. (2020) 27:325–8. 10.1016/j.chom.2020.02.001 - DOI - PMC - PubMed
    1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. . A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. (2020) 382:727–33. 10.1056/NEJMoa2001017 - DOI - PMC - PubMed
    1. Lau SKP, Feng Y, Chen H, Luk HKH, Yang W-H, Li KSM, et al. . Severe Acute Respiratory Syndrome (SARS) coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater horseshoe bats through recombination. J Virol. (2015) 89:10532–47. 10.1128/JVI.01048-15 - DOI - PMC - PubMed
    1. Yuen K-S, Ye Z-W, Fung S-Y, Chan C-P, Jin D-Y. SARS-CoV-2 and COVID-19: the most important research questions. Cell Biosci. (2020) 10:40. 10.1186/s13578-020-00404-4 - DOI - PMC - PubMed

MeSH terms