Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar 23:15:e15.
doi: 10.15420/ecr.2019.15. eCollection 2020 Feb.

Effects of Statin Treatment on Patients with Angina and Normal or Nearly Normal Angiograms

Olivia Manfrini  1 , Peter Amaduzzi  1 , Maria Bergami  1 , Edina Cenko  1
Affiliations
Review

Effects of Statin Treatment on Patients with Angina and Normal or Nearly Normal Angiograms

Olivia Manfrini et al. Eur Cardiol. .

Abstract

This article offers an updated and comprehensive overview of major findings on the effects of statin treatment in patients with chronic angina but without any epicardial coronary artery with obstructive lesion.

Keywords: Statins; cardiac syndrome X; coronary microvascular dysfunction; non-obstructive coronary artery disease; vasospastic angina.

PubMed Disclaimer

Conflict of interest statement

Disclosure: The authors have no conflicts of interest to declare.

References

    1. Ridker PM, Danielson E, Fonseca FA et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359:2195–207. doi: 10.1056/NEJMoa0807646. - DOI - PubMed
    1. Sacks FM, Pfeffer MA, Moye LA et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996;335:1001–9. doi: 10.1056/NEJM199610033351401. - DOI - PubMed
    1. Margaritis M, Sanna F, Antoniades C. Statins and oxidative stress in the cardiovascular system. Curr Pharm Des. 2017;23:7040–7. doi: 10.2174/1381612823666170926130338. - DOI - PubMed
    1. Mart–nez-Gonz–lez J, Raposo B, Rodr–guez C et al. 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation. Arterioscler Thromb Vasc Biol. 2001;21:804–9. doi: 10.1161/01.atv.21.5.804. - DOI - PubMed
    1. Wassmann S, Laufs U, M–ller K et al. Cellular antioxidant effects of atorvastatin in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2002;22:300–5. doi: 10.1161/hq0202.104081. - DOI - PubMed

LinkOut - more resources