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. 2020 Mar 26:8:Doc07.
doi: 10.3205/id000051. eCollection 2020.

Calculated parenteral initial therapy of bacterial infections: Bacterial meningitis

Pramod M Shah  1 , Reinhard Brodt  2 , Thomas A Wichelhaus  3 , Roland Nau  4
Affiliations

Calculated parenteral initial therapy of bacterial infections: Bacterial meningitis

Pramod M Shah et al. GMS Infect Dis. .

Abstract
in English, German

This is the thirteenth chapter of the guideline "Calculated initial parenteral treatment of bacterial infections in adults - update 2018" in the 2nd updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (PEG) has been translated to address an international audience. Bacterial meningitis is a life-threatening infectious disease with high mortality and disability rates requiring prompt initiation of antimicrobial treatment to lower these rates.

Dies ist das 13. Kapitel der von der Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (PEG) herausgegebenen S2k Leitlinie „Kalkulierte parenterale Initialtherapie bakterieller Erkrankungen bei Erwachsenen – Update 2018“ in der 2. aktualisierten Fassung.Die bakterielle Meningitis ist eine lebensbedrohliche Infektionskrankheit mit hohen Mortalitäts- und Invaliditätsraten, die den sofortigen Beginn einer antimikrobiellen Behandlung erfordert, um diese Raten zu senken.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Table 1
Table 1. Calculated antibiotic treatment of bacterial meningitis in adults. The recommendations of the S2k guideline on the treatment of tuberculosis by the German Central Committee for the Control of Tuberculosis e.V. on behalf of the German Society of Pneumology and Respiratory Medicine e.V.
Table 2
Table 2. Targeted antibiotic treatment of bacterial meningitis in adults [according to guidelines of the German Society of Neurology (http://www.dgn.org)]
Table 3
Table 3. Intraventricular antibiotic treatment (usually simultaneous systemic treatment is required)
Table 4
Table 4. Tuberculous meningitis: Dosage recommendations according to national and international guidelines. Due to intolerance or resistance to standard substances of tuberculosis treatment in each case combination treatment with 4 effective tuberculosis drugs should be performed. If necessary, in addition to parenteral administration, only orally available agents (such as PZA, PAS, bedaquiline, delamanid) should be administered. These are therefore also listed in the table.
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References

    1. Bohr V, Hansen B, Jessen O, Johnsen N, Kjersem H, Kristensen HS, Nyboe J, Rasmussen N. Eight hundred and seventy-five cases of bacterial meningitis. Part I of a three-part series: clinical data, prognosis, and the role of specialised hospital departments. J Infect. 1983 Jul;7(1):21–30. doi: 10.1016/S0163-4453(83)90894-0. - DOI - PubMed
    1. Durand ML, Calderwood SB, Weber DJ, Miller SI, Southwick FS, Caviness VS, Jr, Swartz MN. Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med. 1993 Jan;328(1):21–28. doi: 10.1056/NEJM199301073280104. - DOI - PubMed
    1. Robert Koch Institut. Infektionsepidemiologisches Jahrbuch meldepflichtiger Krankheiten für 2014. Berlin: RKI; 2015. - DOI
    1. Marcos MA, Martínez E, Almela M, Mensa J, Jiménez de Anta MT. New rapid antigen test for diagnosis of pneumococcal meningitis. Lancet. 2001 May 12;357(9267):1499–1500. doi: 10.1016/S0140-6736(00)04658-4. - DOI - PubMed
    1. Reiber H, Lange P. Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin Chem. 1991 Jul;37(7):1153–1160. - PubMed

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