Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jun;10(2):150-165.
doi: 10.34172/apb.2020.021. Epub 2020 Feb 18.

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Iti Chauhan  1 , Mohd Yasir  2 , Madhu Verma  1 , Alok Pratap Singh  1
Affiliations
Review

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Iti Chauhan et al. Adv Pharm Bull. 2020 Jun.

Abstract

Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loading, and stability.

Keywords: Lipid; Nanostructure lipid carrier; Skin; Topical.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 2
Figure 2
Figure 3
Figure 3
Figure 4
Figure 4
See this image and copyright information in PMC

References

    1. Mukherjee S, Ray S, Thakur RS. Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian J Pharm Sci. 2009;71(4):349–58. doi: 10.4103/0250-474x.57282. - DOI - PMC - PubMed
    1. López-García R, Ganem-Rondero A. Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC): Occlusive Effect and Penetration Enhancement Ability. J Cosmet Dermatol Sci Appl. 2015;5(2):62–72. doi: 10.4236/jcdsa.2015.52008. - DOI
    1. Poonia N, Kharb R, Lather V, Pandita D. Nanostructured lipid carriers: versatile oral delivery vehicle. Future Sci OA. 2016;2(3):FSO135. doi: 10.4155/fsoa-2016-0030. - DOI - PMC - PubMed
    1. Jain P, Rahi P, Pandey V, Asati S, Soni V. Nanostructure lipid carriers: a modish contrivance to overcome the ultraviolet effects. Egypt J Basic Appl Sci. 2017;4(2):89–100. doi: 10.1016/j.ejbas.2017.02.001. - DOI
    1. Jaiswal P, Gidwani B, Vyas A. Nanostructured lipid carriers and their current application in targeted drug delivery. Artif Cells Nanomed Biotechnol. 2016;44(1):27–40. doi: 10.3109/21691401.2014.909822. - DOI - PubMed

LinkOut - more resources