Dietary Fat Makes Germinal Center B Cells Happy
- PMID: 32375061
- DOI: 10.1016/j.cmet.2020.04.010
Dietary Fat Makes Germinal Center B Cells Happy
Abstract
It is unclear whether ex vivo bona fide distinct types of lymphocytes require the availability of different nutrients in the extracellular environment to support cell growth upon activation. Weisel et al. (2020) recently identified fatty acids as a predominant energy source for ex vivo bona fide germinal center B cell growth.
Copyright © 2020 Elsevier Inc. All rights reserved.
Comment on
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Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis.Nat Immunol. 2020 Mar;21(3):331-342. doi: 10.1038/s41590-020-0598-4. Epub 2020 Feb 17. Nat Immunol. 2020. PMID: 32066950 Free PMC article.
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