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. 2020 Jun 8;12(6):e12634.
doi: 10.15252/emmm.202012634. Epub 2020 May 27.

'All In': a pragmatic framework for COVID-19 testing and action on a global scale

Syril D Pettit  1 , Keith R Jerome  2 , David Rouquié  3 , Bernard Mari  4 , Pascal Barbry  4 , Yasunari Kanda  5 , Mineo Matsumoto  6 , Susan Hester  7 , Leah Wehmas  7 , Jason W Botten  8 , Emily A Bruce  8
Affiliations

'All In': a pragmatic framework for COVID-19 testing and action on a global scale

Syril D Pettit et al. EMBO Mol Med. .

Abstract

Current demand for SARS-CoV-2 testing is straining material resource and labor capacity around the globe. As a result, the public health and clinical community are hindered in their ability to monitor and contain the spread of COVID-19. Despite broad consensus that more testing is needed, pragmatic guidance toward realizing this objective has been limited. This paper addresses this limitation by proposing a novel and geographically agnostic framework (the 4Ps framework) to guide multidisciplinary, scalable, resource-efficient, and achievable efforts toward enhanced testing capacity. The 4Ps (Prioritize, Propagate, Partition, and Provide) are described in terms of specific opportunities to enhance the volume, diversity, characterization, and implementation of SARS-CoV-2 testing to benefit public health. Coordinated deployment of the strategic and tactical recommendations described in this framework has the potential to rapidly expand available testing capacity, improve public health decision-making in response to the COVID-19 pandemic, and/or to be applied in future emergent disease outbreaks.

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Conflict of interest statement

The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency, Japan National Institute of Health Sciences, the Pharmaceuticals and Medical Devices Agency, or that of any of the authors’ employers. The authors have no conflicts to disclose.

Figures

Figure 1
Figure 1. Critical gaps in population‐level COVID‐19 testing
Illustration of contemporary challenges in providing testing to support public health containment of COVID‐19 and key populations that are currently unserved or underserved by testing.
Figure 2
Figure 2. Elements of the 4Ps Framework
Summary of key contributions of each of the four pillars of action.
Figure 3
Figure 3. Applying 4Ps to bridge the gap
Conceptual model of the application of the 4Ps framework to bridge the gap on COVID‐19 testing.
See this image and copyright information in PMC

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