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Observational Study
. 2020 May 6;20(1):135.
doi: 10.1186/s12876-020-01285-0.

Colonic transendoscopic tube-delivered enteral therapy (with video): a prospective study

Ting Zhang  1   2 , Chuyan Long  1   3 , Bota Cui  1   2 , Heena Buch  1   2 , Quan Wen  1   2 , Qianqian Li  1   2 , Xiao Ding  1   2 , Guozhong Ji  1   2 , Faming Zhang  4   5
Affiliations
Observational Study

Colonic transendoscopic tube-delivered enteral therapy (with video): a prospective study

Ting Zhang et al. BMC Gastroenterol. .

Abstract

Background: Colonic transendoscopic enteral tubing (TET) refers to colonic transendoscopic tube-delivered enteral therapy. Colonic TET has been successfully used for frequent colonic administration of drugs or multiple fecal microbiota transplantations (FMTs). This prospective observational study aimed to evaluate possible factors affecting methodology, feasibility and safety of colonic TET.

Methods: Patients who underwent colonic TET at our center from October 2014 to November 2018 were included. The feasibility, efficacy, and safety of TET were evaluated.

Results: In total, 224 patients were analyzed. The success rate of TET was 100%. The median retention time of TET tube within the colonic lumen was 8.5 (IQR 7-11) days in 158 patients with tube falling out spontaneously, and the maximum retention time was up to 28 days. These patients were divided into the short-retention group (≤ 8.5 days) and the long-retention group (> 8.5 days). Univariate and multivariate analysis demonstrated that the type of endoscopic clip (p = 0.001) was an independent factor for the retention time. The larger clips as well as a greater number of clips significantly affected the retention time (p = 0.013). No severe adverse event was observed during and after TET.

Conclusions: Colonic TET is a feasible, practical, and safe colon-targeted drug delivery technique with a high degree of patients' satisfaction. Two to four large endoscopic clips are recommended to maintain stability of the TET tube within the colon for over 7 days.

Keywords: Colonoscopy; Enema; Fecal microbiota transplantation; Method; Transendoscopic enteral tubing.

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Conflict of interest statement

Faming Zhang conceived the concept of GenFMTer and transendoscopic enteral tubing and related devices. Other authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The procedure of colonic TET. a Under endoscopic guidance, the distal TET tube was fixed on the colonic wall with two endoscopic clips. b The TET tube was within the ascending colon. c The TET tube was within the descending colon. d The TET tube was fixed onto the skin of the buttocks
Fig. 2
Fig. 2
Flow chart of the study. NMPA, National Medical Products Administration
See this image and copyright information in PMC

References

    1. Mullish BH, Quraishi MN, Segal JP, McCune VL, Baxter M, Marsden GL, Moore DJ, Colville A, Bhala N, Iqbal TH, et al. The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines. Gut. 2018;67(11):1920–1941. doi: 10.1136/gutjnl-2018-316818. - DOI - PubMed
    1. McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) Clin Infect Dis. 2018;66(7):987–994. doi: 10.1093/cid/ciy149. - DOI - PubMed
    1. Paramsothy S, Kamm MA, Kaakoush NO, Walsh AJ, van den Bogaerde J, Samuel D, Leong RWL, Connor S, Ng W, Paramsothy R, et al. Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet. 2017;389(10075):1218–1228. doi: 10.1016/S0140-6736(17)30182-4. - DOI - PubMed
    1. Costello SP, Hughes PA, Waters O, Bryant RV, Vincent AD, Blatchford P, Katsikeros R, Makanyanga J, Campaniello MA, Mavrangelos C, et al. Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial. JAMA. 2019;321(2):156–164. doi: 10.1001/jama.2018.20046. - DOI - PMC - PubMed
    1. Wang H, Cui B, Li Q, Ding X, Li P, Zhang T, Yang X, Ji G, Zhang F. The safety of fecal microbiota transplantation for Crohn's disease: findings from a Long-term study. Adv Ther. 2018;35(11):1935–1944. doi: 10.1007/s12325-018-0800-3. - DOI - PMC - PubMed

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