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Comment
. 2020 Aug;43(8):547-549.
doi: 10.1016/j.tins.2020.04.006. Epub 2020 May 3.

Connecting Pathological Cellular Mechanisms to Large-Scale Seizure Structures

Quynh-Anh Nguyen  1 , Prannath Moolchand  1 , Ivan Soltesz  2
Affiliations
Comment

Connecting Pathological Cellular Mechanisms to Large-Scale Seizure Structures

Quynh-Anh Nguyen et al. Trends Neurosci. 2020 Aug.

Abstract

Epilepsy is a neurological disorder characterized by recurrent seizures, where abnormal electrical activity begins in a local brain area and propagates before terminating. In a recent study, Liou and colleagues used multiscale computational modeling to gain mechanistic insights into clinical seizure dynamics based on cellular-level biophysical properties.

Keywords: GABA; computational modeling; epilepsy; excitation; inhibition; seizure dynamics.

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Figures

Figure 1.
Figure 1.. Components of the ictal wavefront as modeled by Liou et al. [6].
A) Accumulation of intracellular chloride ahead of the slow ictal wavefront compromises inhibition. B) Inhibition is overcome, and neurons transition from a resting to a tonic firing state as they join the ictal wavefront. C) Tonic firing subsequently activates the slow afterhyperpolarization (sAHP) intrinsic cellular conductance, leading to a hyperpolarizing potassium current to curb neuronal excitability. The tonically firing neurons transition into periods of repetitive burst firing alternating with periods of silence, constituting periodic fast inward traveling waves.
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References

    1. Jirsa VK et al. (2014) On the nature of seizure dynamics. Brain 137, 2210–2230 - PMC - PubMed
    1. Buchin A et al. (2016) Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model. J. Neurosci 36, 11619–11633 - PMC - PubMed
    1. Cressman JR et al. (2009) The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics. J. Comput. Neurosci 26, 159–170 - PMC - PubMed
    1. Ullah G et al. (2009) The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states. II. Network and glial dynamics. J. Comput. Neurosci 26, 171–183 - PMC - PubMed
    1. Farrell JS et al. (2019) Resolving the Micro-Macro Disconnect to Address Core Features of Seizure Networks. Neuron 101, 1016–1028 - PMC - PubMed