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Meta-Analysis
. 2020 Jul:96:131-135.
doi: 10.1016/j.ijid.2020.04.086. Epub 2020 May 4.

Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis

Qianwen Zhao  1 , Meng Meng  2 , Rahul Kumar  3 , Yinlian Wu  4 , Jiaofeng Huang  4 , Yunlei Deng  5 , Zhiyuan Weng  6 , Li Yang  7
Affiliations
Meta-Analysis

Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis

Qianwen Zhao et al. Int J Infect Dis. 2020 Jul.

Abstract

Objectives: Coronavirus Disease 2019 (COVID-19) is a new respiratory and systemic disease which needs quick identification of potential critical patients. This meta-analysis aimed to explore the relationship between lymphocyte count and the severity of COVID-19.

Methods: A comprehensive systematic literature search was carried out to find studies published from December 2019 to 22 March 2020 from five databases. The language of literatures included English and Chinese. Mean difference (MD) of lymphocyte count in COVID-19 patients with or without severe disease and odds ratio (OR) of lymphopenia for severe form of COVID-19 was evaluated with this meta-analysis.

Results: Overall 13 case-series with a total of 2282 cases were included in the study. The pooled analysis showed that lymphocyte count was significantly lower in severe COVID-19 patients (MD -0.31×109/L; 95%CI: -0.42 to -0.19×109/L). The presence of lymphopenia was associated with nearly threefold increased risk of severe COVID-19 (Random effects model, OR=2.99, 95% CI: 1.31-6.82).

Conclusions: Lymphopenia is a prominent part of severe COVID-19 and a lymphocyte count of less than 1.5×109/L may be useful in predicting the severity clinical outcomes.

Keywords: COVID-2019; lymphocyte count; lymphopenia.

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Figures

Fig. 1
Fig. 1
A flow diagram of the inclusion criteria of studies eligible for meta-analysis.
Fig. 2
Fig. 2
Forest plot and funnel plot of all outcomes.
See this image and copyright information in PMC

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