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Review
. 2020 Jul;19(7):102572.
doi: 10.1016/j.autrev.2020.102572. Epub 2020 May 3.

Interleukin-17A (IL-17A), a key molecule of innate and adaptive immunity, and its potential involvement in COVID-19-related thrombotic and vascular mechanisms

Federica Raucci  1 , Adel Abo Mansour  2 , Gian Marco Casillo  1 , Anella Saviano  1 , Francesco Caso  3 , Raffaele Scarpa  3 , Nicola Mascolo  1 , Asif Jilani Iqbal  4 , Francesco Maione  5
Affiliations
Review

Interleukin-17A (IL-17A), a key molecule of innate and adaptive immunity, and its potential involvement in COVID-19-related thrombotic and vascular mechanisms

Federica Raucci et al. Autoimmun Rev. 2020 Jul.
No abstract available

Keywords: COVID-19; IL-17A; Platelet; Thrombus; Vascular diseases.

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Conflict of interest statement

Declaration of Competing Interest This article has been conducted and written in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic representation of inflammatory pathways (left part) involved in the COVID-19-related respiratory syndrome. The inflammatory scenario induced by COVID-19 has cardiovascular implications (right part, top panel) in terms of Th-1/Th-17/T-reg balance that favors the production of IL-17A. The overproduction of this cytokine (right part, bottom panel) amplifies platelet hyper-reactivity and thrombus formation.
See this image and copyright information in PMC

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