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Review
. 2020 Jul;19(7):102570.
doi: 10.1016/j.autrev.2020.102570. Epub 2020 May 3.

Seven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view

Andreas Kronbichler  1 , Maria Effenberger  2 , Michael Eisenhut  3 , Keum Hwa Lee  4 , Jae Il Shin  5
Affiliations
Review

Seven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view

Andreas Kronbichler et al. Autoimmun Rev. 2020 Jul.

Abstract

Now COVID-19 is causing a severe public health emergency and the mortality is rapidly increasing all over the world. In the current pandemic era, although there have been many efforts to diagnose a number of patients with symptoms or close contacts, there is no definite guideline for the initial therapeutic approach for them and therefore, many patients have been dying due to a hyperinflammatory immunological reaction labeled as "cytokine storm". Severe patients are hospitalized and the treatment is done, though they have not been established yet. Currently, however, no treatment is provided for those who are isolated at home or shelter until they get severe symptoms, which will increase the harms to the patients. In this review, we discuss some important points dedicated to the management of patients with COVID-19, which should help reducing morbidity and mortality. In this era, we suggest 7 recommendations to rescue the patients and to reduce the morbidity and mortality due to COVID-19 based on the immunological point of view.

Keywords: COVID-19; Cytokine storm; Early treatment; Mortality.

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Conflict of interest statement

Declaration of Competing Interest All authors confirm to have no actual or potential conflict of interests. The opinions described in this manuscript are those from authors and do not represent the opinions of the journal or other companies.

Figures

Fig. 1
Fig. 1
The pathogenesis of COVID-19 infection and cytokine storm. ALI: acute lung injury; ARDS: acute respiratory distress syndrome; MOF: multiorgan failure; CKD: chronic kidney disease.
See this image and copyright information in PMC

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