Chagas' cardiomyopathy and Lyme carditis: Lessons learned from two infectious diseases affecting the heart
- PMID: 32376493
- DOI: 10.1016/j.tcm.2020.04.004
Chagas' cardiomyopathy and Lyme carditis: Lessons learned from two infectious diseases affecting the heart
Abstract
Chagas' disease and Lyme disease are two endemic, vector-borne zoonotic infectious diseases that impact multiple organ systems, including the heart. Chagas' cardiomyopathy is a progressive process that can evolve into a dilated cardiomyopathy and heart failure several decades after the acute infection; in contrast, although early-disseminated Lyme carditis has been relatively well characterized, the sequelae of Lyme disease on the heart are less well-defined. A century of research on Chagas' cardiomyopathy has generated compelling data for pathophysiological models, evaluated the efficacy of therapy in large randomized controlled trials, and explored the social determinants of health impacting preventative measures. Recognizing the commonalities between Chagas' disease and Lyme disease, we speculate on whether some of the lessons learned from Chagas' cardiomyopathy may be applicable to Lyme carditis.
Keywords: Chagas’ cardiomyopathy; Chagas’ disease; Lyme carditis; Lyme disease.
Copyright © 2020. Published by Elsevier Inc.
Comment in
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Editorial commentary: Chagas' disease and Lyme disease: Are these two endemic diseases so similar?Trends Cardiovasc Med. 2021 May;31(4):240-241. doi: 10.1016/j.tcm.2020.04.007. Epub 2020 Apr 28. Trends Cardiovasc Med. 2021. PMID: 32353469 No abstract available.
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