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Randomized Controlled Trial
. 2020 May 6;10(1):7628.
doi: 10.1038/s41598-020-64365-x.

Different exercise training modalities produce similar endothelial function improvements in individuals with prehypertension or hypertension: a randomized clinical trial Exercise, endothelium and blood pressure

Marinei L Pedralli  1 , Rafael A Marschner  2 , Daniel P Kollet  1 , Salvador G Neto  1 , Bruna Eibel  1 , Hirofumi Tanaka  3 , Alexandre M Lehnen  4
Affiliations
Randomized Controlled Trial

Different exercise training modalities produce similar endothelial function improvements in individuals with prehypertension or hypertension: a randomized clinical trial Exercise, endothelium and blood pressure

Marinei L Pedralli et al. Sci Rep. .

Erratum in

Abstract

Endothelial dysfunction is a characteristic of systemic arterial hypertension (SAH) and an early marker of atherosclerosis. Aerobic exercise training (AT) improves endothelial function. However, the effects of resistance training (RT) and combined training (CT) on endothelial function remain controversial in individuals with SAH. We determined the effects of AT, RT, and CT on endothelial function and systolic (SBP)/diastolic blood pressure (DBP) in individuals with prehypertension or hypertension. Forty-two participants (54 ± 11 y, resting SBP/DBP 137 ± 9/86 ± 6 mmHg) were randomly allocated into AT (n = 14, 40 min of cycling, 50-75% heart rate reserve), RT (n = 14, 6 resistance exercises, 4 × 12 repetitions, 60% maximum strength) and CT (n = 14, 2 × 12 repetitions of RT + 20 min of AT). All participants performed a 40-minute exercise session twice a week for 8 weeks. Endothelial function was evaluated by brachial artery flow-mediated dilation (FMD). Blood pressure was evaluated through ambulatory monitoring for 24 hours. After 8 weeks of exercise training, blood pressure was reduced in all 3 groups: -5.1 mmHg in SBP (95%CI -10.1, 0.0; p = 0.003) in AT; -4.0 mmHg in SBP (95%CI -7.8, -0.5; p = 0.027) in RT; and -3.2 mmHg in DBP (95%CI -7.9, 1.5; p = 0.001) in CT. All 3 exercise training modalities produced similar improvements in FMD: + 3.2% (95%CI 1.7, 4.6) (p < 0.001) in AT; + 4.0% (95%CI 2.1, 5.7) (p < 0.001) in RT; and +6.8% (95%CI 2.6, 11.1) (p = 0.006) in CT. In conclusion, different exercise training modalities were similarly effective in improving endothelial function but impacts on ambulatory blood pressure appear to be variable in individuals with prehypertension or hypertension.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of the SEFRET study.
Figure 2
Figure 2
Ambulatory blood pressure in awake (Panel A), sleep (Panel B) and over 24-hour (Panel C) periods. Data are means ± SD. AT, aerobic training; RT, resistance training; CT, combined training.
Figure 3
Figure 3
Change in blood pressure over 24-hour monitoring.
Figure 4
Figure 4
Flow-mediated dilation, an index of endothelium-dependent vasodilation, before (pre) and after (post) aerobic exercise training (AT), resistance training (RT), and combined training (CT). The results are expressed as mean ± SD.
See this image and copyright information in PMC

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