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Case Reports
. 2019 Aug 21;53(3):306-309.
doi: 10.14744/SEMB.2019.62134. eCollection 2019.

Metachronous Bilateral Acinic Cell Carcinoma of the Parotid Gland in a Young Woman

Vladimír Bartos  1
Affiliations
Case Reports

Metachronous Bilateral Acinic Cell Carcinoma of the Parotid Gland in a Young Woman

Vladimír Bartos. Sisli Etfal Hastan Tip Bul. .

Abstract

Bilateral involvement of major salivary glands by carcinoma of an identical histologic subtype is uncommon. In this study, a 26-year old female patient was diagnosed to have a low-grade acinic cell carcinoma (ACC) in the left parotid gland. After superficial parotidectomy, she was referred to the oncological dispensary care without further oncological therapeutic intervention. During 11 years of follow-up, she had no evidence of locoregional recurrence or metastasis. However, at the age of 37, she was recognized to have another tumor mass in the contralateral parotid gland. Right superficial parotidectomy was done, and histology confirmed an ACC showing the same picture as it was found previously. A year after the operation, no sign of tumor relapse was seen. Although metachronous bilateral ACC of the parotid gland is very rare, it is occasionally encountered in medical practice. Such an event may occur many years after a diagnosis of the initial tumor. Every patient once treated for parotid ACC warrants periodical clinical examinations and long-term follow-up (more than 10 years), even with attention to the contralateral non-affected parotid gland.

Keywords: Acinic cell carcinoma; bilateral involvement; parotid gland.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
The first ACC arising in the left parotid gland. A solid-nodular growth pattern of the neoplastic epithelium. The tumor cell population resembles normal serous acinar salivary gland cells (hematoxylin & eosin, 40x).
Figure 2
Figure 2
PAS staining (the case presented in Figure 1). A multilobular microarchitecture of tumor tissue. The eosinophilic material in the cytoplasm of the neoplastic cells shows a strong purple color (20x).
Figure 3
Figure 3
The second ACC arising in the right parotid gland. The tumor has the same microscopic appearanceas in the previous case (hematoxylin & eosin, 100x).
Figure 4
Figure 4
PAS diastase staining (the case presented in Figure 3). Purple color of the neoplastic cells does persist after digestion with a diastase (100x).
See this image and copyright information in PMC

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