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. 2019 Oct-Dec;15(4):447-453.
doi: 10.4183/aeb.2019.447.

BONE QUALITY IN A YOUNG COHORT OF HIV-POSITIVE PATIENTS

A R Negru  1   2 , C Tiliscan  1   2 , A M Tudor  1   2 , D I Munteanu  1   2 , C Popescu  1   2 , M Lazar  1   2 , A Streinu-Cercel  1   2 , V Arama  1   2 , S S Arama  1   2
Affiliations

BONE QUALITY IN A YOUNG COHORT OF HIV-POSITIVE PATIENTS

A R Negru et al. Acta Endocrinol (Buchar). 2019 Oct-Dec.

Abstract

Context: In HIV+ patients, several factors related to patient and antiretroviral therapy (ART) could determine early onset of bone mineral density (BMD) disturbances.

Objective: Evaluation of bone quality according to gender in patients from the HIV Romanian cohort.

Design: A cross-sectional study in "Prof. Dr. Matei Balş" National Institute for Infectious Diseases, Bucharest between 2016-2018.

Subject and methods: We collected data regarding HIV infection, ART history, viral hepatitis co-infections and we calculated patients body mass index (BMI). CD4 cell count, HIV viral load (VL), vitamin-D levels were determined. Dual-energy X-ray absorptiometry (DXA) scans were used to evaluate BMD.

Results: We enrolled 97 patients with the median age of 26 years. According to the DXA T-scores, 10 males and 8 females had osteopenia and 4 males and 4 females had osteoporosis. According to Z-scores 2 males and 1 female had osteoporosis. Hip DXA T-scores revealed osteopenia in 6 males and 9 females, whereas T and Z-scores showed osteoporosis in 2 males and 3 females. Lumbar spine (LS) T-score diagnosed osteopenia in 9 males and 6 females, while T and Z-scores revealed osteoporosis in 3 males and females. In males, low T-scores were associated with decreased BMI; low LS DXA Z-scores with low vitamin-D levels; low T and Z-scores and LS-BMD with high VL.

Conclusions: Evaluating bone quality in patients with a long history of HIV infection, multiple factors should be taken into account.

Keywords: HIV; gender; osteopenia; osteoporosis.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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