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. 2020 Apr 30;5(1):34.
doi: 10.1038/s41541-020-0188-3. eCollection 2020.

COVID-19 vaccines: breaking record times to first-in-human trials

Affiliations

COVID-19 vaccines: breaking record times to first-in-human trials

Young Chan Kim et al. NPJ Vaccines. .

Abstract

The twenty-first century has come with a new era in vaccinology, in which recombinant genetic technology has contributed to setting an unprecedented fast pace in vaccine development, clearly demonstrated during the recent COVID-19 pandemic.

Keywords: RNA vaccines; Viral infection.

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Conflict of interest statement

Competing interestsThe authors declare no competing interests.

Figures

Fig. 1
Fig. 1. New emerging diseases vaccine development timeline.
Time since the first identification (green) of the virus in a patient or first major outbreak (blue) (and in some cases newly identification) to first Phase I Clinical Trial described. Orange bar represents the time it took to get a licensed Dengue/Ebola vaccine. Red diamonds indicate outbreaks.

References

    1. WHO COVID-19 dashboard. https://covid19.who.int/. (2020).
    1. Rothe, C. et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020. 10.1056/NEJMc2001468. - PMC - PubMed
    1. Wilder-Smith, A. & Freedman, D. O. Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak. J. Travel. Med. 2020. 10.1093/jtm/taaa020. - PMC - PubMed
    1. Bhurani V, Mohankrishnan A, Morrot A, Dalai SK. Developing effective vaccines: cues from natural infection. Int. Rev. Immunol. 2018;37:249–265. doi: 10.1080/08830185.2018.1471479. - DOI - PubMed
    1. Zhou P, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270–273. doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed