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Review
. 2020 Jan 10:2020:3563519.
doi: 10.1155/2020/3563519. eCollection 2020.

Urine-Derived Induced Pluripotent Stem Cells in Cardiovascular Disease

Ping Huang  1   2 , Yibin Li  3 , M I Nasser  1 , Huiming Guo  1 , Huanlei Huang  1 , Mingyi Zhao  4 , Ping Zhu  1
Affiliations
Review

Urine-Derived Induced Pluripotent Stem Cells in Cardiovascular Disease

Ping Huang et al. Cardiol Res Pract. .

Abstract

Recent studies have demonstrated that stem cells are equipped with the potential to differentiate into various types of cells, including cardiomyocytes. Meanwhile, stem cells are highly promising in curing cardiovascular diseases. However, owing to the ethical challenges posed in stem cell acquisition and the complexity and invasive nature of the method, large-scale expansions and clinical applications in the laboratory have been limited. The current generation of cardiomyocytes is available from diverse sources; urine is one of the promising sources among them. Although advanced research was established in the generation of human urine cells as cardiomyocytes, the reprogramming of urine cells to cardiomyocytes remains unclear. In this context, it is necessary to develop a minimally invasive method to create induced pluripotent stem cells (iPSCs). This review focuses on the latest advances in research on urine-derived iPSCs and their application mechanisms in cardiovascular diseases.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Reprogramming of urine cells and differentiation of UiPSCs.
Figure 2
Figure 2
Separation of urine cells. (a)–(d) are type I urine cells ((a) d6, 100×; (b) d6, 400×; (c) d8, 100×; (d) d13, 50×); (e)–(h) are type II urine cells ((e) d6, 100×; (f) d6, 400×; (g) d8, 100×; (h) d13, 50×).
See this image and copyright information in PMC

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