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. 2020 Sep;76(9):3264-3272.
doi: 10.1002/ps.5885. Epub 2020 May 16.

Encapsulation of thiabendazole in hydroxypropyl-β-cyclodextrin nanofibers via polymer-free electrospinning and its characterization

Shuang Gao  1 , Yanyan Liu  1 , Jingyu Jiang  1 , Xiaoming Li  1 , Lixia Zhao  1 , Ying Fu  1 , Fei Ye  1
Affiliations

Encapsulation of thiabendazole in hydroxypropyl-β-cyclodextrin nanofibers via polymer-free electrospinning and its characterization

Shuang Gao et al. Pest Manag Sci. 2020 Sep.

Abstract

Background: Thiabendazole (TBZ) is a poorly water-soluble benzimidazole fungicide. However, the water solubility of TBZ can be significantly enhanced by inclusion complexation with cyclodextrins. In this study, a thiabendazole/hydroxypropyl-β-cyclodextrin (TBZ/HPβCD) complex was synthesized and electrospinning was performed to produce a TBZ/HPβCD nanofibrous (TBZ/HPβCD-NF) complex that improved water solubility and antifungal activity.

Results: The formation of TBZ/HPβCD-NF was characterized by Fourier transform infrared spectroscopy, X-ray diffraction and nuclear magnetic resonance. The morphology of TBZ/HPβCD-NF was studied by scanning electron microscopy. A phase solubility experiment showed that HPβCD exerted a great solubilization effect on TBZ, and TBZ/HPβCD-NF had better antifungal activity compared to that of TBZ alone.

Conclusions: In summary, the solid fungicidal nanodispersion prepared in the present study is a new type of formulation that can enhance the water solubility of TBZ. This formulation, which demonstrated potential as a new fast dissolving formulation type with increased efficacy, is expected to be conducive to the sustainable development of agriculture. © 2020 Society of Chemical Industry.

Keywords: electrospinning; hydroxypropyl-β-cyclodextrin; inclusion complex; nanofibrous; thiabendazole.

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References

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