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. 2020 Jul 10;82(7):903-907.
doi: 10.1292/jvms.19-0692. Epub 2020 May 7.

Comparison of antimicrobial susceptibilities of bacterial isolates between cured and uncured cases of bovine mastitis

Kanako Ishihara  1 , Chihiro Sunagawa  1 , Takashi Haneishi  2   3 , Naoko Miyaguchi  1 , Natsumi Endo  3 , Tomomi Tanaka  3
Affiliations

Comparison of antimicrobial susceptibilities of bacterial isolates between cured and uncured cases of bovine mastitis

Kanako Ishihara et al. J Vet Med Sci. .

Abstract

To evaluate the effect of antimicrobial susceptibility on outcomes, we compared the minimum inhibitory concentrations (MICs) for Staphylococcus, Streptococcus, and the family Enterobacteriaceae from cured and uncured mastitis cases; milk shipment for uncured cases could not be resumed within 3 weeks after initial clinical examination. A higher MIC50 of ampicillin and a higher MIC90 of cefazolin for Enterobacteriaceae isolates were observed for cured rather than uncured cases with differences in ≥2 tubes. Endotoxins are generally released from Enterobacteriaceae upon antimicrobial treatment; their amounts are presumed to be greater in mastitis cases resulting from β-lactam antibiotic-susceptible rather than -resistant microbes. For staphylococcal and streptococcal isolates, the MIC50 and MIC90 of β-lactam antibiotics were similar for cured and uncured cases.

Keywords: antimicrobial resistance; mastitis.

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