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Comment
. 2020 Jul;35(7):1134-1135.
doi: 10.1002/mds.28072. Epub 2020 May 7.

Precision Medicine for Parkinson's Disease: Ambroxol for Glucocerebrosidase-Associated Parkinson's Disease, First Trial Completed

Susanne A Schneider  1 , Roy N Alcalay  2
Affiliations
Comment

Precision Medicine for Parkinson's Disease: Ambroxol for Glucocerebrosidase-Associated Parkinson's Disease, First Trial Completed

Susanne A Schneider et al. Mov Disord. 2020 Jul.
No abstract available

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References

    1. Maegawa GH, Tropak MB, Buttner JD, et al. Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease. J Biol Chem 2009;284:23502-23516.
    1. McNeill A, Magalhaes J, Shen C, et al. Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. Brain 2014;137:1481-1495.
    1. Migdalska-Richards A, Ko WKD, Li Q, Bezard E, Schapira AHV. Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate. Synapse 2017;71. https://doi.org/10.1002/syn.21967
    1. Mullin S, Smith L, Lee K, et al. Ambroxol for the treatment of patients with Parkinson disease with and without glucocerebrosidase gene mutations: a nonrandomized, noncontrolled trial [published online ahead of print January 13, 2020]. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2019.4611

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