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Editorial
. 2020 May 8;126(10):1324-1326.
doi: 10.1161/CIRCRESAHA.120.316981. Epub 2020 May 7.

The March of Monocytes in Atherosclerosis: One Cell at a Time

Rajat M Gupta  1 , Vivian S Lee-Kim  1 , Peter Libby  1
Affiliations
Editorial

The March of Monocytes in Atherosclerosis: One Cell at a Time

Rajat M Gupta et al. Circ Res. .
No abstract available

Keywords: Editorials; atherosclerosis; gene expression; inflammation; monocytes.

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Figures

Figure 1.
Figure 1.
Monocyte and macrophage subsets contribute to the initiation, progression, and thrombus formation stages of atherosclerosis. (A) Bone marrow-derived monocytes in circulation are classified as conventional (cMos) and patrolling (pMos) monocytes. During atherogenesis, the Ly6C+ cMos subpopulation infiltrates the intima, whereas the Ly6C- pMos subpopulation secretes inflammatory cytokines while patrolling the endothelium. (B) In the intima, pro-inflammatory macrophages contribute to plaque progression, while anti-inflammatory macrophages aid in plaque regression. (C) In the Roberts et al. study, genetic ablation of Lyn in mice leads to the expansion of pMos subpopulation only. The Lyn-deficient pMos have increased expression of genes that play a role in heat shock protein response, apoptosis inhibition, and innate immunity, compared to WT pMos. The Lyn-deficient mice are also protected against atherosclerosis.
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References

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