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. 2020 Jun 29;222(2):198-202.
doi: 10.1093/infdis/jiaa252.

T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019

Mei Jiang  1 , Yang Guo  1 , Qing Luo  1 , ZiKun Huang  1 , Rui Zhao  1 , ShuYuan Liu  1 , AiPing Le  2 , JunMing Li  1 , LaGen Wan  1
Affiliations

T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019

Mei Jiang et al. J Infect Dis. .

Abstract

This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4+ T cells but a severe decrease in CD8+ T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8+ T and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.

Keywords: SARS-CoV2; diagnosis; lymphocyte subsets; prognosis.

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