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Comment
. 2020 May 6;106(3):359-361.
doi: 10.1016/j.neuron.2020.04.019.

Tau: A Novel Entry Point for mTOR-Based Treatments in Autism Spectrum Disorder?

Meera E Modi  1 , Mustafa Sahin  2
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Tau: A Novel Entry Point for mTOR-Based Treatments in Autism Spectrum Disorder?

Meera E Modi et al. Neuron. .
Free article

Abstract

Dysregulation of the PI3K/Akt/mTOR pathway has become a point of convergence in autism spectrum disorder (ASD). In this issue of Neuron, Tai et al. (2020) identify a therapeutic role for tau reduction in downregulating this pathway and ameliorating ASD-like symptoms.

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Conflict of interest statement

Declaration of Interests Mustafa Sahin reports grant support from Novartis, Roche, Pfizer, Ipsen, LAM Therapeutics, and Quadrant Biosciences. He has served on scientific advisory boards for Sage, Roche, Celgene, Aeovian, Regenxbio, and Takeda.

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