Why judiciously timed anti-IL 6 therapy may be of benefit in severe COVID-19 infection
- PMID: 32380318
- PMCID: PMC7198409
- DOI: 10.1016/j.autrev.2020.102563
Why judiciously timed anti-IL 6 therapy may be of benefit in severe COVID-19 infection
Keywords: COVID-19; Cytokine storm; IL-6; Interleukin-6; Macrophage activation syndrome; Natural killer cells; Perforin; SARS-CoV-2.
Conflict of interest statement
Declaration of Competing Interest There are no conflicts of interest for any of the authors.
Comment in
-
Re: Patiently waiting for the results of anti-IL 6 therapy in severe COVID-19 infection.Autoimmun Rev. 2020 Jul;19(7):102560. doi: 10.1016/j.autrev.2020.102560. Epub 2020 May 1. Autoimmun Rev. 2020. PMID: 32361193 Free PMC article. No abstract available.
Comment on
-
The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease.Autoimmun Rev. 2020 Jun;19(6):102537. doi: 10.1016/j.autrev.2020.102537. Epub 2020 Apr 3. Autoimmun Rev. 2020. PMID: 32251717 Free PMC article. Review.
References
-
- Voskoboinik I., Whisstock J.C., Trapani J.A. Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol. 2015;15(6):388–400. - PubMed
-
- Cifaldi L., Prencipe G., Caiello I., Bracaglia C., Locatelli F., De Benedetti F. Inhibition of natural killer cell cytotoxicity by interleukin-6: implications for the pathogenesis of macrophage activation syndrome. Arthritis Rheumatol (Hoboken, NJ) 2015;67(11):3037–3046. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous