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. 2020 Jul:191:111013.
doi: 10.1016/j.colsurfb.2020.111013. Epub 2020 Apr 12.

Antioxidative photochemoprotector effects of cerium oxide nanoparticles on UVB irradiated fibroblast cells

Karen E Peloi  1 , César A Contreras Lancheros  2 , Celso V Nakamura  1 , Sushant Singh  3 , Craig Neal  3 , Tamil S Sakthivel  3 , Sudpita Seal  4 , Suelide Oliveira Silva Lautenschlager  5
Affiliations

Antioxidative photochemoprotector effects of cerium oxide nanoparticles on UVB irradiated fibroblast cells

Karen E Peloi et al. Colloids Surf B Biointerfaces. 2020 Jul.

Abstract

The Ultraviolet-B radiation (UVB) might induce cellular redox imbalance which plays an important role in the development of skin disorders. Thus, the search for photochemoprotective alternatives with antioxidant efficacy would be a safe aspect towards prevention of skin diseases. Cerium oxide nanoparticles (CNPs) have antioxidant properties, that are mostly related to CNPs catalase and superoxide dismutase (SOD)-like antioxidative mimetic activity. Considering that, we investigated whether CNPs induce photochemoprotection against UVB-induced cellular damages on L929 fibroblasts. Our results showed that CNPs prevented UVB mediated L929 cell oxidative damage by reestablishing the oxidative balance through ameliorating the reactive oxygen species (ROS) level and enhancing the antioxidant enzyme activities.

Keywords: Antioxidants; Cerium oxide nanoparticles; Fibroblasts; Photochemoprotection; UVB.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that there is no conflict of interest regarding the publication of this article.

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