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Comment
. 2020 Aug;17(8):794-796.
doi: 10.1038/s41423-020-0446-3. Epub 2020 May 7.

The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells

Rens Peeters  1 , Annemiek B van Spriel  2
Affiliations
Comment

The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells

Rens Peeters et al. Cell Mol Immunol. 2020 Aug.
No abstract available

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Figures

Fig. 1
Fig. 1
Summary of metabolic phenotypes of activated lymphocytes. Both activated T cells and activated non-germinal center B cells (non-GC B cells) efficiently take up glucose and catabolize it via glycolysis, as measured by the extracellular acidification rate (ECAR). Activated non-GC B cells partially catabolize glucose in mitochondria (through the TCA cycle), for which they require oxygen (measured by the oxygen consumption rate, OCR). In contrast, GCBCs import negligible amounts of glucose. Instead, they actively take up fatty acids from the environment. Through mitochondrial and peroxisomal fatty acid oxidation (FAO), they fuel the TCA cycle to generate energy.
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References

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