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Review
. 2020 Apr 14:2020:7091718.
doi: 10.1155/2020/7091718. eCollection 2020.

Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis

Yumei Zhang  1 , Songge Guo  1 , Chunyan Xie  1 , Jun Fang  1
Affiliations
Review

Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis

Yumei Zhang et al. Biomed Res Int. .

Abstract

Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives contribute to reduction of cytotoxicity and suppression of drug-induced hepatic steatosis. Uridine is mostly present in blood and cerebrospinal fluid, where it contributes to the maintenance of basic cellular functions affected by UPase enzyme activity, feeding habits, and ATP depletion. Uridine metabolism depends on three stages: de novo synthesis, salvage synthesis pathway and catabolism, and homeostasis, which is tightly relating to glucose homeostasis and lipid and amino acid metabolism. This review is devoted to uridine metabolism and its role in glucose, lipid, and amino acid homeostasis.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
De novo synthesis of uridine: ① carbamoyl phosphate synthetase (CPS II); ② aspartate transcarbamoylase (ATCase); ③ dihydroorotase (DHO); ④ dihydroorotate dehydrogenase (DHODH); ⑤ orotate phosphoribosyltransferase; ⑥ orotidine 5′-phosphate decarboxylase; ⑦ nucleotidase; ⑧ uridine phosphorylase.
See this image and copyright information in PMC

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