Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May 8;15(5):e0232842.
doi: 10.1371/journal.pone.0232842. eCollection 2020.

Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study

Se Hwa Kim  1 , Yumie Rhee  2 , Yoo Mee Kim  1 , Young Jun Won  1 , Junghyun Noh  3 , Hyemi Moon  4 , Juneyoung Lee  4 , Sin Gon Kim  5
Affiliations

Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study

Se Hwa Kim et al. PLoS One. .

Abstract

Objective: The risk of complications of nonsurgical hypoparathyroidism in Asia is unclear. We estimated the prevalence and risk of complications in patients with nonsurgical hypoparathyroidism.

Methods: We performed a retrospective cohort study using a nationwide claims database from 2005 to 2016. Among the entire Korean population, we identified 897 patients diagnosed with nonsurgical hypoparathyroidism during 2005-2015. We selected 210 patients with nonsurgical hypoparathyroidism during 2005-2008 who had no complications at baseline and followed them to 2016. Control subjects (n = 2075) were matched using propensity scores based on age, sex, and comorbid disease with a 1:10 ratio and monitored until 2016.

Results: The age-standardized prevalence of nonsurgical hypoparathyroidism was 0.2 cases per 100,000 persons in 2005. During a mean follow-up period of 9.5 years, patients with nonsurgical hypoparathyroidism had a higher risk of cardiovascular disease, especially arrhythmia (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.11-3.70) and heart failure (HR, 2.43; 95% CI, 1.22-4.83). The risk of vertebral fracture was higher in patients than in controls (HR, 2.27; 95% CI, 1.09-4.72). Patients had a significantly increased risk of renal disease (HR, 2.57; 95% CI, 1.56-4.21), seizure (HR, 5.74; 95% CI, 3.34-9.86), depression and bipolar disease (HR, 1.82; 95% CI, 1.30-2.56), and cataract (HR, 1.90; 95% CI, 1.30-2.79) compared with controls.

Conclusions: The prevalence of nonsurgical hypoparathyroidism was very low in Korea but was associated with a higher risk of incident cardiovascular disease and vertebral fracture as well as known complications including renal disease, seizure, and cataract.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
Kaplan-Meier survival curve of arrhythmia (A) and heart failure (B) in patients with nonsurgical hypoparathyroidism and controls. Hazard ratios (HRs) with 95% confidence intervals (CIs) are shown.
See this image and copyright information in PMC

References

    1. Bilezikian JP, Khan A, Potts JT Jr, Brandi ML, Clarke BL, Shoback D, et al. Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. J Bone Miner Res. 2011;26(10): 2317–2337. 10.1002/jbmr.483 - DOI - PMC - PubMed
    1. Nakamura Y, Matsumoto T, Tamakoshi A, Kawamura T, Seino Y, Kasuga M, et al. Prevalence of idiopathic hypoparathyroidism and pseudohypoparathyroidism in Japan. J Epidemiol. 2000;10(1): 29–33. 10.2188/jea.10.29 - DOI - PubMed
    1. Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study. J Bone Miner Res. 2015;30(9): 1738–1744. 10.1002/jbmr.2501 - DOI - PubMed
    1. Clarke BL, Leibson CL, Emerson JA, Ransom JE, Lagast H. Co-morbid medical conditions associated with prevalent hypoparathyroidism: a population-based study. J Bone Miner Res. 2011; 26: S182 (Abstract SA1070).
    1. Cheol Seong S, Kim YY, Khang YH, Heon Park J, Kang HJ, Lee H, et al. Data Resource Profile: The National Health Information Database of the National Health Insurance Service in South Korea. Int J Epidemiol. 2017;46(3): 799–800. 10.1093/ije/dyw253 - DOI - PMC - PubMed

Publication types

MeSH terms