Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May 6;9(5):594.
doi: 10.3390/foods9050594.

Effect of Yogurt Fermented by Lactobacillus Fermentum TSI and L. Fermentum S2 Derived from a Mongolian Traditional Dairy Product on Rats with High-Fat-Diet-Induced Obesity

Won-Young Cho  1 , Go-Eun Hong  2 , Ha-Jung Lee  1 , Su-Jung Yeon  3 , Hyun-Dong Paik  1 , Yoshinao Z Hosaka  4 , Chi-Ho Lee  1
Affiliations

Effect of Yogurt Fermented by Lactobacillus Fermentum TSI and L. Fermentum S2 Derived from a Mongolian Traditional Dairy Product on Rats with High-Fat-Diet-Induced Obesity

Won-Young Cho et al. Foods. .

Abstract

This study aimed to investigate the metabolic effect of yogurt fermented by Lactobacillus fermentum TSI and S2 isolated from a Mongolian traditional dairy product on rats with high-fat-diet-induced obesity. Quality characteristics of yogurt fermented by commercial starter (CON), L. fermentum TSI2 (TSI2 group), L. fermentum S2 (S2 group), and mixed TSI2 and S2 strains at 1:1 (MIX group), were verified. Six-week-old male Sprague-Dawley rats were divided into five groups and administered the following diets: group NOR, normal diet with oral saline administration; group HF, high-fat diet (HD) with oral saline administration; group TSI, HD and L. fermentum TSI-fermented yogurt; group S2, HD and L. fermentum S2-fermented yogurt; and group MIX, HD and MIX-fermented yogurt. After eight weeks, the HD groups displayed significantly increased body weight and fat, serum cholesterol, and abdominal adipose tissue levels. However, serum HDL cholesterol levels were higher, triglyceride levels were lower, and abdominal adipocytes were smaller in the TSI and S2 groups than in the HF group. These results indicate that L. fermentum TSI reduces abdominal fat and improves blood lipid metabolism in HD-induced obese rats.

Keywords: adipocyte; adiponectin; cholesterol; lactic acid bacteria; mongolian fermented dairy product; yogurt.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Changes in the body weight gain of rats upon oral treatment for 8 weeks.
Figure 2
Figure 2
Representative hematoxylin and eosin staining of omental adipose tissue (OMAT) in SD rats exposed to experimental diet for 8 weeks (original magnification, × 200).
Figure 3
Figure 3
Adipocyte size in abnormal adipose tissue in SD rats on an experimental diet for 8 weeks.
See this image and copyright information in PMC

References

    1. Bourlioux P., Koletzko B., Guarner F., Braesco V. The intestine and its microflora are partners for the protection of the host: Report in Danone symposium the intelligent intestine. Am. J. Clin. Nutr. 2003;78:675–683. doi: 10.1093/ajcn/78.4.675. - DOI - PubMed
    1. Mazza G. Functional Food, Biochemical and Processing Aspects. Taylo and Francis, GP. LLC.; Roca Raton, FL, USA: 1998. pp. 357–374.
    1. Cho Y.H., Shin H.J., Chang C.H., Nam M.S. Studies on the development of the yogurt decreasing blood glucose. Korean J. Food Sci. Anim. Resour. 2006;26:257–262.
    1. Axelsson R. In: Lactic Acid Bacteria: Microbiology and Functional Aspects. Salminen S., von Wright A., editors. Marcel Dekker Inc.; New York, NY, USA: 1998. pp. 1–53.
    1. Parvez S., Malik K.A., Kang S.A., Kim H.Y. Probiotics and their fermented food products are beneficial for health. J. Appl. Microbiol. 2006;100:1171–1185. doi: 10.1111/j.1365-2672.2006.02963.x. - DOI - PubMed