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Review
. 2020 Sep;39(3):625-645.
doi: 10.1007/s10555-020-09887-6.

Wnts and the hallmarks of cancer

Zheng Zhong #  1 , Jia Yu #  1 , David M Virshup  2   3 , Babita Madan  4
Affiliations
Review

Wnts and the hallmarks of cancer

Zheng Zhong et al. Cancer Metastasis Rev. 2020 Sep.

Abstract

Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in cancers have been extensively investigated. Activation of this evolutionarily conserved pathway promotes cancer development via diverse mechanisms. Cancer is a complex disease and one outstanding conceptual framework for understanding its biology is the "Hallmarks of Cancer". In this review, we focus on the involvement of Wnt signaling in the ten hallmarks of human cancer. These widespread roles of Wnt signaling in human cancers highlight the importance and feasibility of targeting this signaling pathway for cancer treatment.

Keywords: Angiogenesis; Cancer; Genome instability; Immune evasion; Inflammation; Metabolism; Metastasis; TERT; Telomeres; Wnt signaling.

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References

    1. Srivastava, M., Begovic, E., Chapman, J., Putnam, N. H., Hellsten, U., Kawashima, T., et al. (2008). The Trichoplax genome and the nature of placozoans. Nature, 454(7207), 955–960. https://doi.org/10.1038/nature07191 . - DOI - PubMed
    1. Nichols, S. A., Dirks, W., Pearse, J. S., & King, N. (2006). Early evolution of animal cell signaling and adhesion genes. Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12451–12456. https://doi.org/10.1073/pnas.0604065103 . - DOI - PubMed - PMC
    1. Loh, K. M., van Amerongen, R., & Nusse, R. (2016). Generating cellular diversity and spatial form: Wnt signaling and the evolution of multicellular animals. Developmental Cell, 38(6), 643–655. https://doi.org/10.1016/j.devcel.2016.08.011 . - DOI - PubMed
    1. Nusse, R., & Varmus, H. E. (1982). Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell, 31(1), 99–109. - DOI
    1. Aoki, K., & Taketo, M. M. (2007). Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. Journal of Cell Science, 120(Pt 19), 3327–3335. https://doi.org/10.1242/jcs.03485 . - DOI - PubMed

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