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Review
. 2020 Jun;83(1):189-212.
doi: 10.1111/prd.12300.

Periodontitis and rheumatoid arthritis: An update 2012-2017

Affiliations
Review

Periodontitis and rheumatoid arthritis: An update 2012-2017

Peter Mark Bartold et al. Periodontol 2000. 2020 Jun.

Abstract

Rheumatoid arthritis and chronic periodontitis are both chronic inflammatory diseases characterized by an exacerbated inflammatory reaction that leads to destruction of bone and other connective tissue. Owing to these similarities, the relationship between these two diseases has been investigated for over two decades. In the 2013 proceedings from a workshop jointly held by the European Federation of Periodontology and American Academy of Periodontology in 2012 it was concluded that there was at least minimal evidence of an association between periodontitis and rheumatoid arthritis. In this review, we consider publications in the field over the past 5 years and determine whether the evidence for this relationship has increased.

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References

    1. Snyderman R, McCarty GA. Analogous mechanism of tissue destruction in rheumatoid arthritis and periodontal disease. In: Genco RJ, Mergenhagen SE, eds. Host-Parasite Interaction in Periodontal Disease. Washington, DC: ASM; 1982:354-362.
    1. Kinloch AJ, Alzabin S, Brintnell W, et al. Immunization with Porphyromonas gingivalis enolase induces. Arthritis Rheum. 2011;63:3818-3823.
    1. Nesse W, Westra J, van der Wal JE, et al. The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol. 2012;39(7):599-607.
    1. Harvey GP, Fitzsimmons TR, Dhamarpatni AA, Marchant C, Haynes DR, Bartold PM. Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. J Periodontal Res. 2013;48(2):252-261.
    1. Linden GJ, Herzberg MC, Working Group 4 of Joint EFP/AAP Workshop. Periodontitis and systemic diseases: a record of discussions of Working Group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40(Suppl 14):S20-S23.

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