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. 2020 Dec 17;71(10):2726-2729.
doi: 10.1093/cid/ciaa502.

Persistence of Clinically Significant Portal Hypertension After Eradication of Hepatitis C Virus in Patients With Advanced Cirrhosis

Cristina Díez  1   2 , Juan Berenguer  1   2 , Luis Ibañez-Samaniego  2   3   4 , Elba Llop  4   5   6 , Leire Pérez-Latorre  1   2 , María V Catalina  2   3   4 , Víctor Hontañón  7   8 , María A Jiménez-Sousa  9 , Teresa Aldámiz-Echevarría  1   2 , Javier Martínez  4   10   11 , José Luis Calleja  4   5   6   12 , Agustín Albillos  4   10   11   13 , José M Bellón  2 , Salvador Resino  9 , Juan González-García  7   8 , Rafael Bañares  2   3   4   14
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Persistence of Clinically Significant Portal Hypertension After Eradication of Hepatitis C Virus in Patients With Advanced Cirrhosis

Cristina Díez et al. Clin Infect Dis. .

Abstract

This prospective study of 34 patients with HCV cirrhosis (17 HIV positive) with baseline clinically significant portal hypertension (CSPH; HVPG ≥10 mmHg) and SVR after DAA therapy showed that disappearance of CSPH (primary endpoint) is a rare event (6/18 patients; 18%), indicating a persistent risk of clinical progression or death.

Keywords: HCV; cirrhosis; direct-acting antiviral agents; eradication; portal hypertension.

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